G-Protein Pathway Suppressor 2 (GPS2) is an inhibitor of non-proteolytic K63 ubiquitination mediated by the E2 ubiquitin-conjugating enzyme Ubc13.Previous studies have associated GPS2-mediated restriction of ubiquitination with the regulation of RCA/AV Cables insulin signaling, inflammatory responses and mitochondria-nuclear communication across di

Abstract With cancer stem cells (CSCs) became the research hotspot, emerging studies attempt to reveal the functions of these special subsets in tumorigenesis.Although various approaches have been used in CSCs researches, only a few could really reflect or simulate the microenvironment in vivo.At present, CSCs theories are still difficult to apply

Abstract Integrated circuit anti-counterfeiting based on optical physical unclonable functions (PUFs) plays a crucial role in guaranteeing secure identification and authentication for Internet of Things (IoT) devices.While considerable efforts have been devoted to exploring optical PUFs, two critical challenges remain: incompatibility with the comp

The Choline escalating importance of lightweight design in engineering demands innovative strategies to tackle this challenge.Traditionally, the joining of these materials involves rivets, bolts, or adhesives.However, contemporary manufacturing techniques, such as 3D printing, present the potential to fabricate joints without the necessity for addi

Dish cloth Terminally differentiated (TD) cells permanently exit the mitotic cycle while acquiring specialized characteristics.Although TD cells can be forced to reenter the cell cycle by different means, they cannot be made to stably proliferate, as attempts to induce their replication constantly result in cell death or indefinite growth arrest.Th